Karnak appears as a NPC in the video game Marvel: Ultimate Alliance
Karnak is a member of the Inhuman race, one of those who form the Inhuman Royal Family, born on the island of Attilan. Cousin of Black Bolt, king of the Inhumans, Karnak has the ability to find the weak point in any person, plan, or object. Thus, he is usually used as planner by the Inhumans. He also serves as a priest and philosopher to the Inhumans.
He is the brother of Triton, who endured Terrigenesis before he did. However, Triton's Terrigenesis was so extreme that his parents, Mander and Azur, begged that Karnak not have to endure the procedure. Instead, he was sent to a monastery, where he learned martial arts. He is usually attended by his relatives, Gorgon and Triton. He has taken part in most of the Inhumans' adventures, such as the Kree-Skrull War, and the many moves of the Inhuman city of Attilan. Karnak and the Royal Family encounter Maximus' creation, the Trikon, and are driven from Attilan's Great Refuge in exile.
Karnak first appeared as a member of the Inhumans when he attempted to retrieve his cousin and queen, Medusa from the outside world and take her back to Attilan. This led him into conflict with the Fantastic Four, the first humans he met, who were harboring Medusa after rescuing her from the villainous Frightful Four. Accordingly, Karnak is indirectly responsible for revealing the existence of Attilan to the outside world. Karnak battled Maximus alongside the Inhuman Royal Family and became trapped in Maximus' "negative zone" barrier around the Great Refuge. He was freed from the "negative zone" barrier along with the rest of the Inhumans by the Fantastic Four and left the Great Refuge with the Royal Family to visit the outside world. He teamed with the Thing, Human Torch, and Black Panther against the Psycho-Man. He aided the Inhuman Royal Family in defeating Maximus' next attempt to overthrow the Great Refuge.
He later assisted Gorgon in freeing Maximus. He journeyed to America to search for the missing Black Bolt. Gorgon battled Magneto and his mutated minions. Karnak later battled Blastaar and the Kree Kaptroids. He traveled to New York City, where he battled Kree agent Shatterstar. Karnak was imprisoned by Maximus. He aided in the defeat of Maximus and the Evil Inhumans. Karnak then left Earth with the Inhuman Royal Family to prevent the Kree subjugation of the Inhumans and battled various aliens. He continued to battle Kree agents, and then returned to Earth. Karnak later accompanied the Inhuman exodus when Attilan was relocated to the Blue Area of Earth's Moon.