Medusa appears as a non-playable character in Marvel: Ultimate Alliance and Marvel Ultimate Alliance 3: The Black Order.
Medusa was the first of two children born to Inhuman nutritionists Quelin and Ambur. Medusa is considered a member of Attilan's Royal Family. Crystal is Medusa's younger sister. Medusa's parents elected to expose her to the mutagenic Terrigen Mist when she was an infant; the process endowed her with hair she could animate like added appendages. While still an adolescent, she began to make frequent visits to the isolation cell of her second cousin, Black Bolt, and learned to communicate with him in a special sign language. Medusa and Black Bolt developed a bond that blossomed into love when Black Bolt was first allowed out of his cell at age 18.
When the Alpha Primitive worker race revolted, Medusa battled their leaders, the Trikon. Her sky sled crashed in the fight and she became an amnesiac wanderer, until the Wizard found her on a small Mediterranean Island, fighting French soldiers. As he was creating an evil version of the Fantastic Four, he needed a woman to join his Frightful Four. Medusa readily agreed and filled out the evil foursome as they tried many times to embarrass and defeat the Fantastic Four. Though they were unsuccessful, their exploits brought Medusa to the attention of her Inhuman family who pursued her. Soon, her cousin Gorgon appeared and chased her along with the Human Torch, who she had forced to help her. A fight between the Human Torch and Medusa awakened the imprisoned Dragon Man, who associated Medusa with the Invisible Girl, who had previously been kind to him. He protected Medusa against Gorgon and the Fantastic Four, until he later captured the Invisible Girl, which distracted the four enough for Gorgon to capture Medusa and bring her back to Black Bolt and her family. She soon stopped fighting her fellow Inhumans and joined them in a fight against the Fantastic Four, who arrived to save the Torch; who had fallen in love with Medusa’s sister, Crystal. But when Crystal announced that Triton had been captured by the Seeker, Medusa gathered around her family and teleported with them to Attilan, using Lockjaw