Karla Sofen, alias Moonstone, is among the villains injected with Mister Fantastic's control nanites, which later became sentient and tried to infect more people and add them to its collective network, The Fold. Moonstone is among the many nanite-controlled villains who ran amok in the Negative Zone prison after Captain America released them in an attempt to cover his forces' escape. The heroes Nick Fury sent in to restore power to the main exit portal defeated her on route to the exit once it was online.

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